Provon CFM® - Ultra pure whey protein isolate (WPI) to fuel the body’s engine

What is Protein?

Protein is a macromolecule consisting of a long chain of amino acids held together by peptide bonds. The chains can vary in length from two amino acids (a dipeptide) to thousands of amino acids. 

It’s included in our bones, muscles, hair, skin and much more.

The Multifaceted Health Benefits of Protein

The numerous and far-reaching health and nutritional benefits of protein make adequate intake crucial to overall health and to specific functions important to today’s consumers.

Key Benefits of Protein Intake

Not All Proteins Are Created Equal

Many different foods contain protein, but the amount and quality of the protein can differ greatly depending on the source. 

Measuring Protein Quality: PDCAAS and DIAAS

Protein Digestibility corrected Amino Acid Score (PDCAAS) and Digestible Indispensable Amino Acid Score (DIAAS) are methods to measure the quality of protein sources.

How is Glanbia Nutritional’s Provon^® CFM superior to other proteins?

Provon CFM whey protein isolate is a compete protein containing optimal amounts of all 9 essential amino acids. These amino acids cannot be made by the body and must come from your diet.

9 Essential Amino Acids (EAAs)

Key Advantages of Provon^® CFM WPI

How do we make Provon^® CFM?

We start with the freshest milk, from trusted farmers, that is delivered to our factories, ensuring the highest quality Provon CFM possible. 

Our milk is used to make cheese, and the whey from cheese is used to make whey protein isolate.

There are two primary technologies for isolating whey proteins from milk. 

1. Ion Exchange process 
2. Cross-flow microfiltration (CFM) process

CFM Process Flow:

CFM whey protein isolate:

• Gentle filtration system that yields a high level of undenatured protein found naturally in whey.
• No chemicals, just filters are used to concentrate the whey.
• Has a superior amino acid profile, with a high BCAA content, less fat, and no lactose, and a higher concentration of beneficial bioactive components.
   

Pioneered and optimized by us, Glanbia’s Provon CFM was the first microfiltered whey protein isolate on the market.

Power your products with the most complete protein available in the market today. You can help your consumers be healthy and fuel their engines.

References: 

1.    Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Walker HK, Hall WD, Hurst JW, editors. Boston: Butterworths; 1990.
2.    The role of albumin in fluid and electrolyte balance. Judy Hankins. J Infus Nurs. 2006 Sep-Oct;29(5):260-5.
3.    Amino acids and immune function. Peng Li 1, Yu-Long Yin, Defa Li, Sung Woo Kim, Guoyao Wu. Br J Nutr. 2007 Aug;98(2):237-52.
4.    Structure and Function of Immunoglobulins. Harry W Schroeder, Jr, M.D., Ph.D. and Lisa Cavacini, Ph.D. J Allergy Clin Immunol. 2010 Feb; 125(2 0 2): S41–S52.
5.    Mg, Zn and Cu Transport Proteins: A Brief Overview from Physiological and Molecular Perspectives. Ayako Hashimoto, Taiho Kambe. J Nutr Sci Vitaminol (Tokyo). 2015:61 Suppl:S116-8.
6.    Cobalamin transport proteins and their cell-surface receptors. Bellur Seetharam, Raghunatha R Yammani. Expert Rev Mol Med. 2003 Jun 13;5(18):1-18
7.    Intestinal cholesterol transport proteins: an update and beyond. Emile Levy, Schohraya Spahis, Daniel Sinnett, Noel Peretti, Françoise Maupas-Schwalm, Edgard Delvin, Marie Lambert, Marc-André Lavoie. Curr Opin Lipidol. 2007 Jun;18(3):310-8
8.    Understanding transporter specificity and the discrete appearance of channel-like gating domains in transporters. George Diallinas. Front Pharmacol. 2014; 5: 207. Published online 2014 Sep 12. Prepublished online 2014 Jul 29.
9.    Prediction of Membrane Transport Proteins and Their Substrate Specificities Using Primary Sequence Information. Nitish K. Mishra, Junil Chang, and Patrick X. Zhao. PLoS One. 2014; 9(6): e100278. Published online 2014 Jun 26.
10.    Effects of short-term energy deficit on muscle protein breakdown and intramuscular proteolysis in normal-weight young adults. John W Carbone, Stefan M Pasiakos, Lisa M Vislocky, Jeffrey M Anderson, Nancy R Rodriguez. Appl Physiol Nutr Metab. 2014 Aug;39(8):960-8.
11.    Dietary protein: an essential nutrient for bone health. Jean-Philippe Bonjour. J Am Coll Nutr. 2005 Dec;24(6 Suppl):526S-36S.
12.    Dietary protein and skeletal health: a review of recent human research. Jane E Kerstetter, Anne M Kenny, Karl L Insogna. Curr Opin Lipidol. 2011 Feb;22(1):16-20.
13.    Dietary Protein and Bone Health. René Rizzoli, Jean-Philippe Bonjour. First published: 02 December 2009 https://doi.org/10.1359/JBMR.040204. 
14.    Dietary protein to maximize resistance training: a review and examination of protein spread and change theories. John D Bosse, Brian M Dixon. J Int Soc Sports Nutr. 2012 Sep 8;9(1):42.
15.    The effects of protein supplements on muscle mass, strength, and aerobic and anaerobic power in healthy adults: a systematic review. Stefan M Pasiakos, Tom M McLellan, Harris R Lieberman. Sports Med. 2015 Jan;45(1):111-31.
16.    Postprandial thermogenesis is increased 100% on a high-protein, low-fat diet versus a high-carbohydrate, low-fat diet in healthy, young women. Carol S Johnston, Carol S Day, Pamela D Swan. J Am Coll Nutr. 2002 Feb;21(1):55-61.
17.    Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet. Margriet A B Veldhorst, Margriet S Westerterp-Plantenga, Klaas R Westerterp. Am J Clin Nutr. 2009 Sep;90(3):519-26.
18.    Presence or absence of carbohydrates and the proportion of fat in a high-protein diet affect appetite suppression but not energy expenditure in normal-weight human subjects fed in energy balance. Margriet A B Veldhorst 1, Klaas R Westerterp, Anneke J A H van Vught, Margriet S Westerterp-Plantenga. Br J Nutr. 2010 Nov;104(9):1395-405.
19.    Protein catabolism and requirements in severe illness. L Genton, C Pichard. Int J Vitam Nutr Res. 2011 Mar;81(2-3):143-52.
20.    Protein and Amino Acid Requirements during Pregnancy. Rajavel Elango and Ronald O Ball. Adv Nutr. 2016 Jul; 7(4): 839S–844S.
21.    Nutrition Recommendations in Pregnancy and Lactation. Michelle A. Kominiarek, Priya Rajan, Med Clin North Am. 2016 Nov; 100(6): 1199–1215.
22.    Protein intakes are associated with reduced length of stay: a comparison between Enhanced Recovery After Surgery (ERAS) and conventional care after elective colorectal surgery. Sophia E Yeung, Leslee Hilkewich, Chelsia Gillis, John A Heine, Tanis R Fenton. Am J Clin Nutr. 2017 Jul;106(1):44-51.
23.    Protein Requirements and Recommendations for Older People: A Review. Caryl Nowson and Stella O’Connell. Nutrients. 2015 Aug; 7(8): 6874–6899.
24.    Dietary protein for athletes: from requirements to optimum adaptation. Stuart M Phillips, Luc J C Van Loon. J Sports Sci. 2011:29 Suppl 1:S29-38.
25.    The Cell: A Molecular Approach. 2nd edition. Cooper GM.Sunderland (MA): Sinauer Associates; 2000.
26.    Endocrinology: An Integrated Approach. Nussey S, Whitehead S. Oxford: BIOS Scientific Publishers; 2001.
27.    Acid-Base Homeostasis. L. Lee Hamm, Nazih Nakhoul, Kathleen S. Hering-Smith. Clin J Am Soc Nephrol. 2015 Dec 7; 10(12): 2232–2242.
28.    Protein Buffering in Model Systems and in Whole Human Saliva. Andreas Lamanda, Zeinab Cheaib, Melek Dilek Turgut, Adrian Lussi. PLoS One. 2007; 2(2): e263.
29.    A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. David S Weigle, Patricia A Breen, Colleen C Matthys, Holly S Callahan, Kaatje E Meeuws, Verna R Burden, Jonathan Q Purnell. Am J Clin Nutr. 2005 Jul;82(1):41-8.
30.    Effects of protein intake and gender on body composition changes: a randomized clinical weight loss trial. Ellen M Evans, Mina C Mojtahedi, Matthew P Thorpe, Rudy J Valentine, Penny M Kris-Etherton, Donald K Layman. Nutr Metab (Lond). 2012 Jun 12;9(1):55.
31.    High protein intake sustains weight maintenance after body weight loss in humans. M S Westerterp-Plantenga, M P G M Lejeune, I Nijs, M van Ooijen, E M R Kovacs. Int J Obes Relat Metab Disord. 2004 Jan;28(1):57-64.
32.    Energy expenditure and protein requirements after traumatic injury. David Frankenfield. Nutr Clin Pract. 2006 Oct;21(5):430-7.
33.    The importance of patients' nutritional status in wound healing. L Russell. Br J Nurs. 2001 Mar;10(6 Suppl):S42, S44-9.
34.    Whey Protein Supplementation Enhances Whole Body Protein Metabolism and Performance Recovery after Resistance Exercise: A Double-Blind Crossover Study. Daniel W. D. West, Sidney Abou Sawan, Michael Mazzulla, Eric Williamson, and Daniel R. Moore. Nutrients. 2017 Jul; 9(7): 735.
35.    Whey protein supplementation in muscle hypertrophy. C Sobral, D Gomes, M Silva, P Martins, A Baltazar. European Journal of Public Health, Volume 30, Issue Supplement_2, June 2020, ckaa040.004
36.    https://www.idahomilkproducts.com/comparing-pdcaas-with-diaas-which-is-…